Leo obtained his Ph.D. from the Chemistry Department at the University of Manitoba in 1996 under the supervision of Dr. Joe O'Neil. His graduate research involved application of solution NMR methods to the study of membrane protein dynamics. Following his graduate research, Leo was a Heart and Stroke Foundation postdoctoral fellow in the laboratory of Dr. Brian D. Sykes in the CIHR group in Protein Structure and Function at the University of Alberta. His postdoctoral studies involved determination of the structures, interactions, and dynamics of heart muscle proteins using solution state NMR methods. Subsequent to postdoctoral studies, he was appointed Assistant Professor of Biochemistry in the Department of Biochemistry at the University of Alberta in 2000. Leo was an AHFMR Medical Research Scholar from 2001-2006 and a AHFMR Medical Research Senior Scholar from 2006-2013. His main research interests are studies of proteins involved the ubquitination cycle using NMR methods.